Fenghai Guo

Assistant Professor


Headshots002FenghaiGuoEd-size.jpg

Department: Chemistry
Office Location: FLA140 Contact: FLA 140 601 S. Martin Luther King Jr. Drive Department of Chemistry Winston Salem State University Winston Salem, North Carolina 27110
Phone: 336-750-3158
Fax: 336-750-2549
Email:  guof@wssu.edu
Curriculum Vitae

Educational Background

  • Ph.D., Clemson University
  • B.A., Shanghai Jiaotong University

  • Research and Project Interests:

  • Synthetic methodology development; total synthesis of bioacitve natural products and heterocyclic compounds
  • Heterocycles continue to be the focus of intense synthetic activity both in academia and industry. Over 75% of the top 200 brand name drugs are heterocycles. Heterocycles also account for more than 50% of all known organic compounds. In nature, heterocycles are active components for defense, communication, and reproduction. Their rich activity in biological systems is important for pharmaceuticals, agricultural, and natural products. As a result, there has been increasing interest in the efficient synthesis of heterocycles. Synthesis of complex heterocyclic molecules, including both unnaturally and naturally occurring targets, has had tremendous impact on the development of chemistry, biology and medicine. The goal of this project is to develop novel metal-catalyzed asymmetric carbon carbon bond formation strategies that will greatly increase the efficiency in complex heterocycle synthesis. Lengthy synthetic sequences, low efficiencies in most multi-step syntheses make it extremely challenging to provide sufficient quantities of desired targets for drug discovery. The inefficiency is often due to the limited availability of efficient carbon carbon bond formation methods. Our goal is to develop efficient asymmetric carbon carbon bond formation reactions for heterocycle synthesis. Further mechanistic studies and synthetic application of these novel reactions will allow the rapid syntheses of various complex heterocycles.

  • Selected Publications:

    Oxidative Coupling of Enolates, Enol Silanes, and Enamines: Methods and Natural Product Synthesis" Guo, F. Clift, M., Thomson, R. J. Eur. J. Org. Chem. 2012, 4881-4896.

    "Regio- and Stereoselectivity in the Reactions of Organometallic reagents with Ethyl (E) 4,5-Epoxy-2-hexenoate and (E) 1-(tert-Butyldimethylsilyloxy)-2,3-epoxy-4-hexene: Applications for Sequential Bis-allylic Substitution Reactions" Dieter, R. K., Huang, Y., Guo, F. J. Org. Chem., 2012, 77, 4949-4967.

    "Enantioselective Total Synthesis and Studies into the Configurational Stabilities of Bismurrayaquinone A." (ASAP published online) Konkol, L. C.; Guo, F.; Sarjeant, A. A.; Thomson, R. J. Angew. Chem. Int. Ed. 2011, 50, 9931-9934.
    This paper is highlighted in SYNFACTS, 2011, 12, 1270

    "Enantioselective Synthesis of Biphenols from 1,4-Diketones by Traceless Central-to-Aixal Chirality Exchange." Guo, F.; Konkol, L. C.; Thomson, R. J. J. Am. Chem. Soc. 2011, 133, 18-20.

    "Hydroxyl-directed Borylative Cyclization of 1,6-Enynes." Camelio, D.; Barton, T.;
     Guo, F.; Siegel, D. Org. Lett., 2011, 13, 1517-1519.
    This paper is highlighted in SYNFACTS, 2011, 06, 0631

    "Conjugate Addition Reactions of N-Carbamoyl-4-Pyridones with Organometalic Reagents." Dieter, R. K.; Guo, F. J. Org. Chem. 2009, 74, 3843-3848.

    "Tandem Regio- and Stereoselective Organocuprate Mediated Bis-Allylic Substitutions." Dieter, R. K.; This paper is highlighted in SYNFACTS, 2008, 07, 0714 . Guo, F. Org. Lett2006, 8, 4779-4782.

    "A Rapid Divergent Synthesis of Highly Substituted delta-Lactones." Dieter, R. K.; Guo, F. Org. Lett. 2006, 8, 4779-4782.

    Conference Presentations:

    Guo, F. ACS National Meeting, New Orleans, LA, United States, April 7-11, 2013. (Oral presentation)

    Guo, F. (SERMACS, Nov. 2012). The 64th Southeastern Regional Meeting of the American Chemical Society, Raleigh, NC. (Oral Presentation)

    Konkol, L. C.; Guo, F.; Thomson, R. J. April, 2012. The 4th Annual Chicago Organic Symposium, Chicago, Illinois. (Poster)

    Guo, F.; Konkol, L. C.; Jones, B.; Thomson, R. J. February, 2011. The 3th Annual Chicago Organic Symposium, Chicago, Illinois. (Poster)

    Guo, F.; Konkol, L. C.; Jones, B.; Thomson, R. J. May, 2011. Industrial Associate Meeting, Evanston, Illinois. (Poster)

    Clift, M. D.; Hu, D. X.; Konkol, L. C.; Guo, F.; Thomson, R. J. April, 2010. The 2th Annual Chicago Organic Symposium, Evanston, Illinois. (Poster)

    Guo, F., Dieter, R.K. (2008, August). 236th American Chemical Society National Meeting, Philadelphia, PA, United States, August 17-21, (Oral Presentation).

    Holstein, P., Guo, F., Dieter, R. K. (2008, August). 236th ACS National Meeting, Philadelphia, PA, United States, August 17-21, 2008 (ACS) (Poster Presentation)

    Guo, F., Dieter, R.K. (2008, April). 235th American Chemical Society National Meeting, New Orleans, LA, United States, April 6-10, 2008 (Oral Presentation).

    Guo, F., Dieter, R.K. (2007, October). 59th SERMACS, Greenville, SC, United States, October 24-27, 2007 (Oral Presentation).


    Additional Information:

    Organic Chemistry I (Fall, 2012), Organic Chemistry I lab (Fall, 2012)

    Organic Chemistry II (Spring, 2013), Organic Chemistry II lab (Spring, 2013)

     

    Winston-Salem State University

    601 S. Martin Luther King Jr. Drive

    Winston-Salem, NC 27110

    Phone: (336) 750-2000



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