Maria Ngu-Schwemlein, Ph.D.

Professor


Ngu-SchwemleinMaria.jpg

Department: Chemistry
Office Location: Chemistry Department W.B. Atkinson Science Bldg., Rm 309
Phone: 336-750-2919
Fax: 336-750-2545
Email:  schwemleinmn@wssu.edu
Curriculum Vitae

Biography

Dr. Maria Ngu-Schwemlein received her B.Sc. degree in Chemistry, with Honors, in 1985 from LaTrobe University, Victoria, Australia.  In 1989, she earned her Ph.D. degree in Medicinal/Organic Chemistry at the John Curtin School of Medical Research at the Australian National University (ANU) in Canberra, Australia.  She is a Professor of Bioorganic Chemistry in the Department of Chemistry.  Her research interests are in peptide derived ligands for metal ions sensing and as potential antimicrobial agents.  She is formally trained in medicinal chemistry and has more than eighteen years of experience in teaching and advising both graduate and undergraduate students.  Since joining Winston-Salem State University in 2006, she has received funding from both NSF and NIH for her research in antimicrobial and metal ion binding peptides.  Dr. Ngu-Schwemlein is a member of the national American Chemical Society, American Peptide Society, and the Council for Undergraduate Research (UCUR).


Educational Background

  • Ph.D., Medicinal/Organic Chemistry, The Australian National University, Australia, 1989
  • B.Sc., (Honors), Chemistry, LaTrobe University, Australia, 1985

  • Research and Project Interests:

  • Rational Design of Cysteinyl Peptide Ligands as Chelators of Mercury(II)
  • Enhancing In Vitro Antimicrobial Activity of Common Antibiotics with Cyclopeptides

  • Selected Publications:

    PUBLICATIONS (undergraduates co-authors*)

    Synthesis and ESI mass spectrometric analysis of the association of mercury(II) with multi-cysteinyl peptides, Maria Ngu-Schwemlein, Xiuli Lin, Brent Rudd, Matthew Bronson*, Journal of Inorganic Biochemistry, 2014, 133, 8-23.

    In vitro synergy between some cationic amphipathic cyclooctapeptides and antibiotics, Maria Ngu-Schwemlein, Jenna Dumond, Lisa Rudd, Jean-Herbert Rigaud*, Australian Journal of Chemistry (Manuscript CH14427, just accepted August, 2014, abstract available on line)

    Evaluation of the association of mercury(II) with some dicysteinyl tripeptides, X. Lin, J. Brooks*, M. Bronson*, M. Ngu-Schwemlein, Bioorganic Chemistry, 2012, 44, 8-18. http://dx.doi.org/10.1016/j.bioorg.2012.06.001

    Secondary Structural Preferences of Some Antibacterial Cyclooctapeptides in the Presence of Calcium(II),  Tarshona Stevens*, NykiaMcNei*l, Xiuli Lin, and Maria Ngu-Schwemlein, International Journal of Medicinal Chemistry, 2012,  Article ID 730239, doi:10.1155/2012/730239

    1,2-Dihydro-9H-carbazole-4(3H)-thione, W.A. Phelan, M. Ngu-Schwemlein, F.R. Fronczek, M.L. McLaughlin, S.F. Watkins, Acta Crystallographica, 2011, E67, o757.

    Thermodynamics of the complexation of Hg(II) by cysteinyl peptide ligands using isothermal titration calorimetry, M. Ngu-Schwemlein, J. Merle, Patrick Healy*, S. Schwemlein*, Sade Rhodes*, Thermochimica Acta, 2009, 496, 129-135.

    Fluorogenic Cyclooctapeptides and Metal Ion Sensing.  M. Ngu-Schwemlein, L. Garcia, A. Kshawna*, In Proceedings of the Twentieth American Peptide Symposium Series: Advances in Experimental Medicine and Biology, Vol. 611, Peptides for Youth, (E. Escher, W. D. Lubell, S. D. Valle, Eds), 2009, pg. 87-8.

    Thermodynamics and Fluorescence Studies of the Interactions of Cyclopeptides with Hg2+, Pb2+ and Cd2+, Maria Ngu-Schwemlein, Willie Gilbert*, Kshawna Askew*, Stefanie Schwemlein*, Bioorganic and Medicinal Chemistry, 2008, 16 (10), 5778-5787.

    Recombinant Expression of the b subunit of HLA-DR10 for the Selection of Novel Lymphoma Targeting Molecules, Huguette Albrecht, Monique Cosman, Maria Ngu-Schwemlein, Michele Corzett, Kena W. Curran, Cheryl Dolan, Xiangming Fang, Sally J. DeNardo, Gerald L. DeNardo and Rod Balhorn, Cancer Biother Radiopharm. 2007 22(4):531-42.

    Interactions of an Acidic Cyclooctapeptide with Metal Ions: Microcalorimetric and Fluorescence Analyses, Maria Ngu-Schwemlein, Peter Butko, Brian Cook*, Tiffany Whigham*, J. Peptide Research, 2005, 66 (Supplement s1), 72-81.

    Amphipathic Cyclooctapeptides: Interactions with Detergent Micelles and Metal Ions.  William Day Gates*, Jack Rostas*, Bobby Kakati*, and Maria Ngu-Schwemlein, J. Mol. Str., 2005, 733(1), 5-11.

    Extracellular Domain of Myelin Oligodendrocyte Glycoprotein (MOG) Exhibits Solvent-Dependent Conformational Transitions. Maria Ngu-Schwemlein, Michele Corzett, Kevin H. Thornton, Rod Balhorn, Monique Cosman, Protein and Peptide Lett., 2003, 10 (5), 483-490.

    Synthesis and Calcium Interactions of Model Amphiphatic Cyclic Peptides in Detergents.  Day Gates*, Jack Rostas*, Victor Bailey*, Maria Ngu-Schwemlein, In Proceedings of the Eighteenth American Peptide Society Symposium (Chorev, M. and Sawyer, T.K., Eds), 2003, 424-425.

    Cyclotetrapeptides with alternating D-Ala residues: synthesis and spectroscopic studies. M. Ngu-Schwemlein, F. Zhou, T. Bowie*, R. Eden*, J. Mol. Str., 2003, 655 (1), 59-68.

    Synthesis of Paucidisperse Poly(gamma-benzyl-alpha, L-glutamate) Oligomers and Star Polymers with Rigid Arms.  X. Wang, W. Daly, P. Russo, M. Ngu-Schwemlein, Biomacromol., 2001, 2(4), 1214-1219.

    CD Evidence of Conformational Transitions in rMOG[1-125] in the Presence of Membrane Mimicking Detergents.  M. Ngu-Schwemlein, M. Corzette, R. Balhorn, M. Cosman, In Proceedings of the Seventeenth American Peptide Society Symposium (Houghten, R.A. and Lebl, M., Eds), 2001, 334-5.

    Conformational Studies of Cyclotetrapeptides [Xaa-D-Ala]2 by NMR, CD and Molecular Modeling.  M. Ngu-Schwemlein, T. Bowie*, R. Eden*, F. Zhou, In Proceedings of the Seventeenth American Peptide Symposium (Houghten, R.A. and Lebl, M., Eds), 2001, 287-8.

    Polymeric Cyclic Peptides as Self-Assembling Biopolymers.  M. Appeanin*, C. Agbasi*, M. Ngu-Schwemlein, Proceedings of the 26th Annual NOBBChE Conference, 1999, 26, 109-116.

    Imidazo[1,2-b]pyridazines. XXII. Syntheses of Some 2-Aryl-3-methoxy-6-(pyridinylmethylthio and pyridinylmethylamino)imidazo[1,2-b]pyridazines and their Interaction with Central and Mitochondrial Benzodiazepine Receptors.  G.B. Barlin, L.P. Davies, S.J. Ireland, M. Ngu-Schwemlein, Aust. J. Chem., 1997, 50, 91-95.

    Synthesis of gama-Benzyl-alpha, L-glutamate Oligomers and their Star Derivatives.  X. Wang, W. Daly, M. Ngu-Schwemlein, Polymer Preprints, 37(1): 622-623, 1996.

    A Practical Method for Preparing Peroxynitrite Solutions of low Ionic Strength, free of Hydrogen Peroxide.  W.A. Pryor, R. Cueto, X. Jin, W.H. Koppenol, M. Ngu-Schwemlein, G.L. Squadrito, R.M. Uppu, Free Radical Biol. Med., 18:75-83 (1995).

    Substituted imidazo[1,2-b]pyridazines. New Compounds with activity at Central and Peripheral Benzodiazepine Receptors.  L.P. Davies, G.B. Barlin,  S.J. Ireland, M.M.L. Ngu, Biochem. Pharm., 1992, 44, 1555.

    Imidazo[1,2-b]pyridazines. VIII. Syntheses and Central Nervous System Activities of Some 6-Benzylamino(and methoxybenzylamino)-3-methoxy-2-phenyl (substituted phenyl or pyridyl)imidazo[1,2-b]pyridazines. G.B. Barlin, L.P. Davies, and M. Ngu, Aust. J. Chem., 1989, 42, 1759.

    Imidazo[1,2-b]pyridazines. VII. Syntheses and Central Nervous System Activities of Some 3-Alkoxy-6-benzyloxy(methoxybenzyloxy)-2-phenyl (substituted phenyl or pyridyl)imidazo[1,2-b]pyridazines. G.B. Barlin, L.P. Davies, and M. Ngu, Aust. J. Chem., 1989, 42, 1749.

    Imidazo[1,2-b]pyridazines. VI. Syntheses and Central Nervous System Activities of Some 3-(Alkoxy- and methylthio-phenoxy and methoxybenzylthio)-3-methoxy-2-phenyl(substituted phenyl and  pyridyl)imidazo[1,2-b]pyridazines. G.B. Barlin, L.P. Davies, S.J. Ireland and M. Ngu, Aust. J. Chem., 1989, 42, 1735.

    Imidazo[1,2-b]pyridazines. V. Syntheses and Central Nervous System Activities of Some 3-Alkoxy-6-benzylthio(substituted benzylthio and other phenylalkylthio)-2-(and substituted phenyl)imidazo[1,2-b]pyridazines. G.B. Barlin, L.P. Davies, and M. Ngu, Aust. J. Chem., 1989, 42, 1133.

    Imidazo[1,2-b]pyridazines. IV. Syntheses and Central Nervous System Activities of Some 3-Methoxy-6-phenoxyimidazo[1,2-b]pyridazines. G.B. Barlin, L.P. Davies, and M. Ngu, Aust. J. Chem., 1988, 41, 1735.

    Imidazo[1,2-b]pyridazines. III. Syntheses and Central Nervous System Activities of Some 6-Chloro-3-methoxy(and ethoxy)-2-aryl(and heteroaryl)-imidazo[1,2-b]pyridazines.  G.B. Barlin, L.P. Davies, and M. Ngu, Aust. J. Chem., 1988, 41, 1149-1156.

    An Improved Synthesis of Porphyrin C. P.A. Scourides, G. Morstyn, and M. Ngu, J. Chem. Soc., Chem Commun., 1986, 1917.

    Heterocyclic Amplifiers of Phleomycin. X. Derivatives of Diazine Mono- and Di-thiols. G.B. Barlin, D.J. Brown, B.J. Cronin, and M. Ngu, Aust. J. Chem., 1986., 39: 69-75.


    Additional Information:

    “Targeted Infusion Project: Enhancing Undergraduate Research Experience in the Chemistry Curriculum at WSSU” PI (Maria Ngu-Schwemlein), Co-PIs (Brown, Merle, Kiren, Yakubu) 9/1/2014 to 8/31/2017 (Funded)

     “Fulbright STEM Scholar-in-Residence (SIR) at Winston-Salem State University”, PI (Maria Ngu-Schwemlein), Co-PIs (Joti Sekhon, and Mamudu Yakubu) 7/15/2014 to 5/15/2015) (FUNDED)

    “AAAS WIRC-MI: International collaboration in cysteinyl-peptide functionalized carbon nanodots as chelators and sensors for mercury ion”, PI (Maria Ngu-Schwemlein): 11/1/2012-12/31/2013.

    “RUI: Rational Design of Cysteinyl Peptide Ligands as Chelators of Mercury(II)”, NSF Grant # CHE1011859, Principal Investigator (Maria Ngu-Schwemlein), Co-PIs (John Merle, Sayo Fakayode: 7/15/2010-6/30/2014.

    “Enhancing In Vitro Antimicrobial Activity of Common Antibiotics with Cyclopeptides”, NIH NIGMS SC3, Grant # 1SC3GM088134-0, Principal Investigator, 8/01/2009-7/31/2014.

    “Targeted Infusion Grant: Enhancing the Undergraduate Biochemistry Experience by Implementing a Concentration in Biochemistry within the Chemistry Program” National Science Foundation grant HRD 0714900, PI and Coordinator (PI: Chair of Department, Dr. A. Mohammed), 2007-2009.

    “Instrumentation to Enhance Education and Research at Winston-Salem State University”, DoD, Army Research Office, Co-PI (PI: Dr. M. Yakubu), 2007-2009.

    “RUI: Rational Design of Fluorogenic Cyclopeptides as Sensors for Metal Ions” National Science Foundation Grant # CHE-0613675, Principal Investigator, 2006-2009. (Transferred grant from University of South Alabama).

    20th American Peptide Symposium, Montreal, Canada, June 25-30, 2007: Fluorogenic Cyclooctapeptides and Metal Ion Sensing.  M. Ngu-Schwemlein, L. Garcia, A. Kshawna.

    NSF Joint Annual Meeting, Washington DC, June 16-19, 2008: Implementation of a Biochemistry Concentration to Enhance the Undergraduate Biochemistry Experience, M. Ngu-Schwemlein, J. Harp, A. Mohammed

    POGIL Southeast Regional Annual Meeting, Statesboro, GA, July 27-29, 2009: Improving Student Achievement in Sophomore Organic Chemistry by Enhancing Active Learning with Technology. M. Ngu-Schwemlein

    238th National American Chemical Society Meeting, Washington DC, August 16-20, 2009: 

    Guided Inquiry Learning in the Chemistry Laboratory Experience, Abdul Mohammed, Sayo Fakayode, Mamudu Yakubu, Maria Ngu-Schwemlein.

    POGIL Southeast Regional Annual Meeting, Williamsburg, VA, June 30-July 2, 2010: Guided Inquiry Learning in the Chemistry Laboratory Experience, Mamudu Yakubu, Maria Ngu-Schwemlein, Sayo Fakayode, Abdul Mohammed, Angela King.

    240th National American Chemical Society Meeting, Boston, MA, Division of Medicinal Chemistry August 22-26, 2010:  Synthesis and structural studies of the antimicrobial action of some amphipathic cyclopeptides, Maria Ngu-Schwemlein, Nykia McNeil, C-F Zhu, Melissa Bovell.

    242th National American Chemical Society Meeting, Denver, CO, Division of Medicinal Chemistry August, 2011:  Enhancing In-vitro Antimicrobial Activity of Common Antibiotics with Cyclopeptide

    Maria Ngu-Schwemlein, Lisa Rudd, Tarshona Stevens

    SERMACS 2011 ACS Southeastern Regional Meeting, Richmond, VA, October 26-29, 2011: A Study of the complexation of Hg(II) with some cysteinyl peptides by electrospray ionization mass spectrometry, Xiuli Lin, Maria Ngu-Schwemlein, Christa Colyer

    SERMACS 2012 ACS Southeastern Regional Meeting, Raleigh, NC, November 14-17, 2012: Evaluation of synergism from combination of some cyclopeptides and antibiotics, Jenna Dumond, Lisa Rudd, Jean-Herbert Rigaud, Destiny Walter, Maria Ngu-Schwemlein

    246th National American Chemical Society Meeting, Indianapolis, IN, September 8-12, 2013: Elucidation of the association of mercury(II) with cysteinyl peptides for chelation therapy, Maria Ngu-Schwemlein, Xiuli Lin, Matthew Bronson, Brent Rudd

    HBCU-UP Research Conference, Washington, DC, Oct 4-7, 2007: Cyclopeptides: Metal Ion Binding and Sensing, Willie Gilbert, Stephanie Jackson, Maria Ngu-Schwemlein.

    Student Presenter, Willie Gilbert, received the first place award for this research presentation at this conference.

    235th National American Chemical Society Meeting, New Orleans, April 6-10, 2008: Thermodynamic studies of the chelation of mercuric ions by amino acids and derivatives, Patrick Healy, Willie Gilbert, Maria Ngu-Schwemlein

    235th National American Chemical Society Meeting, New Orleans, April 6-10, 2008: 

    Interactions of cyclopeptides containing Cys2His2 or Met2His2 residues and Hg2+, Pb2+ and Cd2+, Kshawna Askew and Maria Ngu-Schwemlein

    HBCU-UP Research Conference, Washington, DC, Oct 23-26, 2008: Interactions of cyclopeptides containing Cys2/His2 or Met2/His2 residues with some common heavy metal ions g, Kshawna Askew, Maria Ngu-Schwemlein.

    237th National American Chemical Society Meeting, Salt Lake City, UT, March 22-26, 2009: Chelation of mercury (II) by peptide ligands containing cysteinyl and histidyl residues, Sade Rhodes, Aisha Hilliard, John Merle, Maria Ngu-Schwemlein

    238th National American Chemical Society Meeting, Washington DC, August 16-20, 2009: 

    Computational studies of chelation of mercury (II) by peptide ligands containing cysteinyl residues John Merle, Maria Ngu-Schwemlein, Jamar Thomas, Alicia McClain.

    HBCU-UP Research Conference, Washington, DC, Oct 22-25, 2009: Complexation of Mercury (II) by Peptide Ligands containing Cysteinyl and Histidyl residues, Sade Rhodes, Maria Ngu-Schwemlein

    10th Annual Biomedical Research Conference for Minority Students (ABRCMS), Charlotte, NC, November 10-13, 2010: Synthesis and Structure-Antimicrobial Activity Correlation Study of Some Amphipathic Cyclopeptides, Tarshona Stevens, Nykia McNeil, Melissa Bovel, Maria Ngu-Schwemlein.

    242th National American Chemical Society Meeting, Denver, CO, Division of Analytical Chemistry August, 2011:  Rational design of cysteinyl peptide ligands as chelators of mercury(II), Jeremy Brooks, Brent Rudd, Maria Ngu-Schwemlein

    2011 Sigma Xi Annual Meeting & International Research Conference, Raleigh Convention Center, NC, November 10-13, 2011: Rational design of cysteinyl peptides as chelators of mercury(II), Matthew Bronson and Jeremy Brooks, Adviser: M. Ngu-Schwemlein

     

    The 12th Annual Poster and Vendor Night, April 3, 2012, Sponsored by Syngenta and the Central North Carolina Section of ACS: Rational design of cysteinyl peptides as chelators of mercury(II), Matthew Bronson, M. Ngu-Schwemlein

    (Student Presenter, Matthew Bronson, received the second place award for this research presentation at this meeting.

    Winston-Salem State University Scholarship Day, April 9, 2013:  Evaluation of synergism from combination of some cyclopeptides and antibiotics, Jean-Herbert Rigaud, Jenna Dumond, Lisa Rudd, Maria Ngu-Schwemlein

    13th Annual Biomedical Research Conference for Minority Students (ABRCMS), Nashville, TN, November 11-16, 2013: Evaluation of synergism from combination of some cyclopeptides and antibiotics, Jean-Herbert Rigaud, Jenna Dumond, Lisa Rudd, Maria Ngu-Schwemlein.

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