Tennille D. Presley
Position: Assistant Professor of Physics Department: Chemistry
Contact Info
Office: 141 F.L. Atkins Annex Phone: 336-750-3202 Fax: 336-750-2549 Email: presleyt@wssu.edu
Biography
Dr. Presley is an Assistant Professor of Physics in the Department of Chemistry at Winston-Salem State University. Her research focus is to provide a better understanding of contributing factors to vascular dysfunction and blood disorders (such as nitric oxide and heat shock proteins) as they relate to overall functional health in diabetic individuals in the African American population. Currently, she is studying the influence of heat treatment on hyperglycemia and how this effect contributes to changes in the availability of nitric oxide and the fragility of hyperglycemic red blood cells. Furthermore, she intends to explore mechanisms to enhance the interaction of heat shock proteins and nitric oxide in diabetic individuals through diet manipulation and exercise. Dr. Presley is also interested in examining biomarkers of diabetes to augment earlier detection of the disease and investigate how various biomarkers may differ in African Americans in comparison to other populations where diabetes is not as prevalent.
Educational Background
- Post-Doctoral Training, Physics & Translational Science, 2007-2010, Wake Forest University
- PhD, Biophysics, 2007, The Ohio State University
- BS, Interdisciplinary Physics, 2002, North Carolina A & T State University
Silverstein, M. D. Ordanes, A.T. Wylie, D.C. Files, C.E. Milligan, T.D. Presley, K. Kavanagh. Inducing Muscle Heat Shock Protein 70 Improves Insulin Sensitivity and Muscular Performance in Aged Mice. J Geront Biol Sci, 2014 (in press).
Jessup, J.A., H. Wang, L.M. Macnamara, T.D. Presley, D.B. Kim-Shapiro, L. Zhang, A.F. Chen, L. Groban. Estrogen Therapy, Independent of Timing, Improving Cardiac Structure and Function in Oophorectomized mRen2.Lewis Rats. Menopause 20(8):860-868, 2013.
Miller, G.D., A.P. Marsh, R.W. Dove, D. Beavers, T.D. Presley, C. Helms, E. Bechtold, S.B. King, D.B. Kim-Shapiro. Plasma Nitrate and Nitrite are Increased by a High Nitrate Supplement, But Not By High Nitrate Foods in Older Adults. Nutrition Research 32(3):160-168, 2012.
Jessup, J.A., L. Zhang, T.D. Presley, D.B. Kim-Shapiro, H. Wang, A.F. Chen, L. Groban. 2011. Tetrahydrobiopterin Restores Diastolic Function and Attenuates Superoxide Production in Ovariectomized mRen2.Lewis Rats. Endocrinology 152:2428-2436, 2011.
Jessup, J.A., L. Zhang, A.F. Chen, T.D. Presley, D.B. Kim-Shapiro, M.C. Chappell, H. Wang, L. Groban. Neuronal Nitric Oxide Synthase Inhibition Improves Diastolic Function and Reduces Oxidative Stress in Ovariectomized mRen2.Lewis Rats. Menopause 18:698-708, 2011.
Presley, T.D., A.R. Morgan, E. Bechtold, W. Clodfelter, R.W. Dove, J.M. Jennings, R.A. Kraft, S.B. King, P.J. Laurenti, W.J. Rejeski, J.H. Burdette, D.B. Kim-Shapiro, and G.D. Miller. Acute Effect of a High Nitrate Diet on Brain Perfusion in Older Adults. Nitric Oxide 24:34-42, 2011.
Presley, T.D., K. Vedam, L.J. Druhan, and G. Ilangovan. Hyperthermia-Induced Hsp90-eNOS Preserves Mitochondrial Respiration in Hyperglycemic Endothelial Cells by Down-Regulating Glut-1 and Up-Regulating G6PD Activity. J Biol Chem 285(49):38194-38203, 2010.
Dobroshielski, DA., T.D. Presley, A. Perlegas, A.P. Marsh, D.B. Kim-Shapiro, and W.J. Rejeski. Plasma Nitrite Response in Older Women to a Physical Function Test. Aging Clin Exp Res 22(1):1-4, 2009.
Presley, T.D., A. Perlegas, L. Bain, S. Ballas, J. Nichols, H. Sabio, M. Gladwin, G. Kato, and D. Kim-Shapiro. Effects of a Single Sickling Event on the Mechanical Fragility of Sickle Trait Erythrocytes. Hemoglobin34(1):24-36, 2009.
Presley, T.D., K. Vedam, X. Liu, J.L. Zweier, and G. Ilangovan. Activation of Hsp90/NOS and Increased NO Generation Does Not Impair Mitochondrial Respiratory Chain by Competitive Binding at Cytochrome c Oxidase in Low Oxygen Concentrations. Cell Stress Chaperones 14(6):611-627, 2009.
Presley, T.D., M. Velayutham, K. Vedam, J. Zweier, and G. Ilangovan. Activation of Hsp90-eNOS and Increased NO Generation Attenuates Respiration in Hypoxia-Treated Endothelial Cells. Am J Physiol Cell Physiol 295(5):C1281-C1291, 2008.
Jones, C., Z. Han, T.D. Presley, S. Varadharaj, J. Zweier, G. Ilangovan, and B. Alevriadou. Endothelial cell respiration is affected by the oxygen tension during shear exposure: Role of mitochondrial peroxynitrite. Am J Physiol Cell Physiol 295(1):C180-C191, 2008.
He, X., I. Azarov, A. Jeffers, T.D. Presley, J. Richardson, S. King, M. Gladwin, and D. Kim-Shapiro. The potential of Angeli’s salt to decrease nitric oxide scavenging by plasma hemoglobin. Free Rad Biol Med.44:1420-1432, 2008.
Presley, T.D., P. Kuppusamy, J.L. Zweier, and G. Ilangovan. EPR Oximetry as a Quantitative Tool to Measure Cellular Respiration: A Consideration of Oxygen Diffusion Interference. Biophys J. 91:4623-31, 2006.
Presley, T.D., P. Kuppusamy, J.L. Zweier, and G. Ilangovan. The Role of Heat Shock Protein 90 and Endothelial Nitric Oxide Synthase Signaling in Cardiovascular Therapy. Curr Sign Trans Ther. 1(3):305-315, 2006.
Presley, T.D., P. Kuppusamy, J.L. Zweier, and G. Ilangovan. The Role of Heat Shock Protein 90 and Endothelial Nitric Oxide Synthase Signaling in Cardiovascular Therapy. Curr Sign Trans Ther. 1(3):305-315, 2006.
- PHY 2321-General Physics I
- PHY 2121-General Physics I Lab
- PHY 2322-General Physics II
- PHY 2122-General Physics II
- PHS 2336-Physical Science
- PHS 2136-Physical Science Lab
- PHY 3325-Introduction to Biophysics
Improvements in Type II Diabetes Utilizing Acute Heat and Exercise, Emory University STEM Research and Career Symposium (2014)
Heat Acclimation Improves HSPs and NO Bioavailability in a Type 2 Diabetic Rodent Model, Fifth International Meeting on the Role of Nitrite and Nitrate in Physiology, Pathophysiology, and Therapeutics(2013)
The Effect of Heat Acclimation on Type II Diabetes, Emory University STEM Research and Career Symposium (2013)
STEM Summer Immersion Program, Association of American Colleges and Universities Next Generation STEM Learning: Investigate, Innovate, Inspire (2012)
Effect of Heat Acclimation on a Type 2 Diabetic Rodent Model, 13th Research Centers in Minority Institutions (RCMI) International Symposium on Health Disparities (2012)
NO Scavenging and Hemolysis in Sickle Cell Disease, The Carolina Biophysics Symposium (2010)
.An Acute Effect of a High Nitrate Diet on Brain Perfusion in Older Adults, The Society of Free Radical Biology in Medicine Meeting (2010)
A Novel Method to Measure Nitrite and Nitrosyl Hemoglobin in Whole Blood Using Electron Paramagnetic Resonance Spectroscopy, The Society of Free Radical Biology in Medicine Meeting(2009)
The Mechanism of Hemolysis in Sickle Cell Anemia, The American Society of Hematology Meeting(2008)
An EPR Oximetry Measurement of Reduced Oxygen Consumption in Endothelial Cells at Hyperglycemic Conditions, The 12th In Vivo EPR Spectroscopy and Imaging/9th International EPR Spin Trapping Conference (2007)
Exposure to Extreme Hypoxia Attenuates Endothelial Cellular Respiration: A Potential Role of Hsp90-eNOS Association, 51st Annual Meeting of the Biophysical Society (2007)
Wake Forest University Physics Colloquium (2014)
University of North Carolina at Chapel Hill Physics Symposium (2014)
University of the District of Columbia Faculty Mentoring & Advocacy Symposium (2014)
University of Pittsburgh Vascular Medicine Institute (2014)
Winston-Salem State University Faculty Advising Institute (2014)
Thurgood Marshall College Fund Member-Universities Professional Institute (2014)
Wake Forest University Translational Science Center Freshman Seminar (2013)
Wake Forest University Translational Science Center Full Body Meeting (2013)
Winston-Salem State University RAM Radio (2013)
North Carolina A & T State University Physics Colloquium (2012)
Wake Forest University Translational Science Center Freshman Seminar (2012)
MARC and RISE Seminar (2010)
Carolina Biophysics Symposium (2010)