Victor M. Pulgar
Victor M. Pulgar received his PhD in Sciences from University of Chile in Santiago, Chile. After postdoctoral work in Chile and The Netherlands he moved to Winston-Salem, NC, in 2003. Currently Dr. Pulgar is a Research Scientist Associate with the Biomedical Research Infrastructure Center at Winston-Salem State University (WSSU) and an Assistant Professor Adjunct at Wake Forest School of Medicine (WFSM) in the Obstetrics and Gynecology Department and a faculty member of the Hypertension & Vascular Research Center also at WFSM. With varied interests Dr. Pulgar’s research focus on the local vascular mechanisms in animal models of cardiovascular diseases. Dr. Pulgar’s research investigates alterations in vascular contractility of peripheral arteries (i.e. mesenteric) as well as placental and uterine vessels from genetic rodent models of hypertension, IUGR, hypertensive pregnancy and preeclampsia. He also provides instruction for undergraduate and graduate students as a mentor for the MARC Program (at WSSU), the Excellence in Cardiovascular Sciences Program and as Course Director for IPP715-Techniques in Physiology (at WFSM). Dr. Pulgar is actively involved in peer review for several journals and e-Books, acting as editorial board member in two journals, and as a member of the American Heart Association - Vasc Endo2 Peer Review Study Group.
- Postdoctoral, 2002, University of Chile, Santiago, Chile and Academic Hospital Maastricht, AZM Maastricht, The Netherlands
- PhD in Sciences, 1999, University of Chile, Santiago, Chile.
- BSc Biochemistry, 1992, University of Chile, Santiago, Chile.
Research and Project Interests
- Vascular physiology and pharmacology
- Maternal hemodynamics in pregnancy
- Physiological responses to hypoxia
- Antenatal glucocorticoids and postnatal blood pressure
- Cardiovascular effects of drugs of abuse
- Biomedical properties of natural compounds.
- Individual-Environment interactions in marine species
Articles published in the last 5 years. See full list of peer-reviewed publications in Pubmed
Brosnihan KB, Pulgar VM, Gallagher PE, Neves LAA, Yamaleyeva LM. Local uterine Ang-(1-7) infusion augments the expression of cannabinoid receptors and differentially alters endocannabinoid metabolizing enzymes in the decidualized uterus of pseudopregnant rats. Rep Biol Endocrinol 2015 Jan 17;13(1):5. doi:10.1186/1477-7827-13-5 [Epub ahead of print] PMID: 25596750.
Pulgar J, Lagos P, Maturana D, Valdés M, Aldana M, Pulgar VM. Effect of UV radiation on habitat selection by Girella laevifrons and Graus nigra (Kyphosidae). J Fish Biol. 2015 Jan 4. doi: 10.1111/jfb.12566. [Epub ahead of print] PMID: 25557650.
Pulgar VM, Yamaleyeva LM, Varagic J, McGee CM, Bader M, Dechend R, Howlett AC, Brosnihan KB. Increased ANG II contraction of the uterine artery at early gestation in a transgenic model of hypertensive pregnancy is reduced by inhibition of endocannabinoid hydrolysis. Hypertension. 2014;64(3):619-25. PMID: 24935942.
Pulgar VM and Keith Harp J. Vascular effects of diphenylmethoxypiperidine-derived dopamine uptake inhibitors. Bioorg Med Chem Lett. 2014;24(11):2429-2432. PMID: 24792462
Molina P, Ojeda JP, Aldana M, Pulgar VM, Garcia-Huidobro RM, Pulgar J. Spatial and temporal variability in subtidal macroinvertebrates diversity patterns in a management and exploitation area for benthic resources (MEABRs). Ocean Coast Manag. 2014;93:121-128.
Pulgar J, Poblete E, Alvarez M, Morales J, Aldana M, Aranda B, Pulgar VM. Can upwelling signals be detected in intertidal fishes with different trophic levels? J Fish Biol 2013;83:1407-1415 PMID:24117929.
Su Y, Carey LC, Rose JC, Pulgar VM. Antenatal glucocorticoid exposure enhances the inhibition of adrenal steroidogenesis by leptin in a sex-specific fashion. Am J Physiol Endocrinol Metab. 2013;304(12):E1404-E1411 PMID: 23632631.
Zepeda AB, Figueroa CA, Pessoa Jr A, Castillo RL, Pulgar VM, Farías JG. Cellular and molecular mechanisms in the hypoxic tissue: role of HIF-1 and ROS. Cell Biochem Funct. 2013 31(6):451-459 PMID: 23760768.
Farias JG, Jimenez D, Osorio J, Zepeda AB, Figueroa CA, Pulgar VM. Acclimatization to chronic intermittent hypoxia in mine workers: a challenge to mountain medicine in Chile. Biol Res. 2013;46(1):59-67 PMID: 23730416.
Pulgar VM, Jeffers AB, Rashad HM, Diz DI, Aileru AA. Increased constrictor tone induced by ouabain-treatment in rats. J Cardiovasc Pharmacol. 2013;62(2):174-182 PMCID: PMC3893306.
Pulgar J, Aldana M, Alvarez M, Garcia-Huidobro R, Molina P, Morales JP, Pulgar VM. Upwelling affects food availability, impacting the morphological and molecular conditions of the herbivorous limpet Fissurella crassa (Lamarck 1882) (Mollusca: Archaeogastropoda) J Mar Biol Assoc U.K. 2013;93(3):797-802.
Su Y, Carey L, Rose JC, Pulgar VM. Leptin alters adrenal responsiveness by decreasing expression of ACTH-R, StAR and P450c21 in hypoxemic fetal sheep. Reprod. Sci. 2012;19(10):1075-1084. PMID: 22534336.
Pulgar J, Alvarez M, Delgadillo A, Herrera I, Benitez S, Morales JP, Molina P, Aldana M, Pulgar VM. Impact of wave exposure on seasonal morphological and reproductive responses of the intertidal limpet Fissurella crassa (Mollusca: Archaeogastropoda) J Mar Biol Assoc U.K. 2012;92(7):1595-1601 doi:10.1017/S0025315412000173.
Moraga FA, Reyes RV, Herrera EA, Riquelme RA, Ebensperger G, Pulgar VM, Parer JT, Giussani DA, Llanos AJ. Role of the α-adrenergic system in femoral vascular reactivity in neonatal llamas and sheep: a comparative study between highland and lowland species. Am J Physiol Regul Integr Comp Physiol. 2011 301(4):R1153-60. PMID: 21795632.
Pulgar VM, Yamashiro H, Rose JC, Moore LG. Role of the AT2 receptor in modulating the angiotensin II contractile response of the uterine artery at mid-gestation. J Renin Angiotensin Aldosterone Syst. 2011 12(3):176-83. PMID: 21421654.
Pulgar J, Alvarez M, Morales J, Garcia-Huidobro M, Aldana M, Ojeda FP, Pulgar VM. Impact of oceanic upwelling on morphometric and molecular indices of an intertidal fish Scartichthys viridis (Blenniidae). Mar Freshw Behav. Physiol. 2011 44(1):33-42.
Llanos AJ, Ebensperger G, Herrera EA, Reyes RV, Pulgar VM, Serón-Ferré M, Díaz M, Parer JT, Giussani DA, Moraga FA, Riquelme RA. Fetal and postnatal pulmonary circulation in the Alto Andino. Placenta 2011 32(Suppl 2):S100-3. PMID: 21295346
Pulgar VM, Hong JK, Jessup JA, Massmann AG, Diz DI, Figueroa JP. Mild chronic hypoxemia modifies expression of brainstem angiotensin peptide receptors and reflex responses in fetal sheep. Am J Physiol Regul Integr Comp Physiol. 2009 297(2):R446-52. PMID: 19515988.
Dept. of Experimental Cytology, University of Porto, Portugal 06-08/1995
Protein Kinase CK1 from Drosophila melanogaster Embryo and its Relations to DNA Repair.
Laboratory of Molecular Biology of Malignant Transformation, USP, Brazil 06-08/1996
Cloning and Expression of CK1 Proteins in Mammalian Cells
Dept. of Biological Chemistry, University of Padova, Padova, Italy, 08-11/1997
Structural and Biochemical Properties of CK1 Kinases; Point Mutations
Andromaco Laboratories, Santiago, Chile, 12-2011
Evaluation of Contraceptive Compounds in Rat
Dept. of Chemical Engineering, University La Frontera, Temuco, Chile 12-2011
Potential Cardiovascular Properties of Native Chilean Berries
GPCR-mediated Mechanisms of Vascular Control
Research Triad International, Raleigh, NC, 6-2012
Interactions between Renin-Angiotensin and Endocannabinoid Systems
Research Triad International, Raleigh, NC, 9-2013
Uterine Artery Reactivity in Rodent Models of IUGR and Preeclampsia
Grünenthal Group Chile, Santiago, Chile, 12-2013
Contraceptive Effects of Meloxicam in Wistar rats
Dept. of Chemical Engineering, University La Frontera, Temuco, Chile, 12-2013
Reactive Oxygen Species in Health and Disease
Dept. of Pediatrics, Catholic University, Santiago, Chile, 12-2013
Programming of Adrenal Function by Antenatal Glucocorticoids
Dept. of Chemical Engineering, University La Frontera, Temuco, Chile, 11-2014
Lipid Mediators in Vascular Control during Pregnancy
Fetal and Neonatal Physiological Society (FNPS) 2002-2005
Society for Gynecologic Investigation (SGI), In-Training Member 2006-2008
American Physiological Society (APS), 2010-present
Sex/Gender-Related Research Interest Group
American Heart Association (AHA), High Blood Pressure Research Council, 2011-present
Research Mentor for the Excellence in Cardiovascular Sciences Summer Program
Hypertension & Vascular Research Center, Wake Forest School of Medicine, NC, 2011-present.
Research Mentor for the Minority Access to Research Careers Undergraduate
Student Training in Academic Research (MARC U*STAR) Program, BRIC, 2011-present.
Excellence in Cardiovascular Sciences Program (WFSM), Member of Review Panel 2011-present.
Scholars Research Day, Judge, Winston-Salem State University (WSSU), 2011-present.
Course Instructor for BIO 2311 - Anatomy & Physiology I, WSSU Fall 2013.
Course Instructor for Investigation & Research Course for MARC Students - BRIC, 2015-present.
Member of the Integrated Physiology and Pharmacology (IPP) Graduate Program, 2011-present
Wake Forest School of Medicine (WFSM), Winston-Salem, NC.
Visiting Professor - Cellular and Molecular Applied Science Ph.D. Program, University La Frontera,
Graduate Students & Postdoctoral Research Day Judge, Wake Forest University, 2011-present
IPP715 Techniques in Physiology Course (at WFSM): Ex vivo vessels, Wire Myography, 2011-
IPP715 Techniques in Physiology (at WFSM): Course Director, 2013-present
Member of IPP Curriculum Committee (at WFSM), 2014-present